Differential uptake of amyloid-β soluble oligomers and fibrils by human microglia

b aggregates into non-b aggregates. Both oligomeric and filbrillar Ab can induce microglial activation, however the cellular signal ways are different due to the TNFa and iNOS mRNA expression levels, and NO metabolites activity are different when the BV2 cells were co-incubated with oligomeric and filbrillar Ab40, respectively.Ab-Cu(II) complexs play less roles on the activation of microglial than both oligomeric and fibrillar Ab. Conclusions: These results indicated that oligomeric and fibrillar Ab induce differentially activation of BV-2 cells and which were dramatically attenuated by Cu(II).