Aggressive Large-Cell Lymphomas

Aggressive large-cell lymphomas (diffuse large B-cell lymphoma, peripheral T-cell lymphoma, and systemic anaplastic large-cell lymphoma) account for approximately 30%, 6%, and 2% of newly diagnosed non-Hodgkin’ s lymphomas, respectively (1). Although they are clearly different diseases biologically, these illnesses share a number of clinical characteristics. The epidemiology, pathogenesis/biology, diagnosis, and treatment of these disorders is discussed in this chapter.