Volume preserving elastic transformation for local breast-tissue quantification

In this paper, we explore the idea of quantifying local breast-tissue density changes. Breast tissue density has been correlated to breast cancer incidence in numerous studies which have shown a statistical relationship between glandular density and the occurrence of cancer. In particular, postmenopausal women who take HRT run an increased risk of developing cancer due to the “regeneration” of fibroglandular tissue that is often induced by the exogenous hormones. In this paper, we present a method that combines mammogram normalisation and volume-preserving registration, and which can be the starting point for temporal-local breast tissue quantification.