A DNA Repair Inhibitor Isolated from an Ecuadorian Fungal Endophyte Exhibits Synthetic Lethality in PTEN-Deficient Glioblastoma.

Nneoma Adaku,Hyun Bong Park,Daniel Spakowicz,Meetu Kaushik Tiwari,Scott A. Strobel,Jason M. Crawford,Faye A. Rogers

A DNA Repair Inhibitor Isolated from an Ecuadorian Fungal Endophyte Exhibits Synthetic Lethality in PTEN-Deficient Glioblastoma.

2020

Nneoma Adaku
Hyun Bong Park
Daniel Spakowicz
Meetu Kaushik Tiwari
Scott A. Strobel
Jason M. Crawford
Faye A. Rogers

Disruption of the tumor suppressor PTEN, either at the protein or genomic level, plays an important role in human cancer development. The high frequency of PTEN deficiency reported across several c...

Keywords:

Biochemistry
Glioblastoma
Synthetic lethality
human cancer
Cancer research
Suppressor
PTEN
Fungal endophyte
Biology

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