[Prevention of the adverse effects of head-down tilting on the infrastructure of body fluids and postural stability of primates by exposure to g-loads].

2004 
: Experiments with 24 primates (Macaca mulatta) demonstrated that head-down tilting (-5 degrees) altered their hydration status as was manifested by a significant diminution of the amount of extracellular fluids, the interstitial fraction specifically. Blood circulation in leg muscles reduced almost in half In addition, return of the animals to the orthostatic position at the end of the experiment did not cause so intensive blood redistribution in leg vessels as in the group of tilted but not rotated animals.
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