Benzofurans or benzothiophenes-Aminoalquilbenzoil, their method of preparation and compositions containing them.

2001 
Benzofuran derivatives or benzothiophene general formula: ** (See formula) ** and pharmaceutically acceptable salts thereof, wherein: A represents a C1-C5 alkylene, straight or branched, optionally substituted with a hydroxyl group, or a represents a group of general formula: ** (See formula) ** in which R19 and R20, identical or different, each represent a C1-C4 linear or branched alkylene group R30 and R31, taken together, They represent a carbonyl group with the carbon to which they are attached or represent a group of general formula: ** (See formula) in which R29 ** represents a C1-C4, T represents hydrogen or an alkyl radical C1- C4, R represents: - the cyano group, formyl or tetrazolyl, - an ester group of general formula: ** (See formula) ** wherein R4 represents an alkyl group C1-C5 linear or branched, or cycloalkyl C3- C6, - a carboxyl group of general formula: ** (See formula) ** wherein R5 represents the hydrophilic geno or an alkali metal atom, - an amide group of general formula: ** (See formula) ** wherein R6 and R7, identical or different, represent hydrogen or an alkyl radical, linear or branched C1-C4 or R6 and R7 when taken together represent an alkylene chain C2-C6, - a ketone group of general formula: ** (See formula) ** wherein R8 represents an alkyl group C1-C4, - a group oxime of general formula: ** (See formula) ** wherein R9 represents hydrogen or C1-C4 alkyl radical, - a carboxyl group of general formula: ** (See formula) ** in which R10 represents a alkylene, linear or branched, C1-C4 alkyl, R11 represents hydrogen or an alkyl C1-C4, R12 represents a radical C1-C4 alkyl or R11 and R12 alkyl, when taken together, represent a C2-C6 alkylene chain, - a group of general formula: ** (See formula) ** in which R32 and R33, identical or different, represent an alkyl group C1-C4, linear or branched, R1 represent to an alkyl group C1-C6 linear or branched or R1 represents a group of general formula: ** (See formula) ** wherein R23 represents a C1-C6 linear or branched, R2 and R3, identical or different alkylene group , represent hydrogen, linear or branched alkyl group C1-C6, optionally substituted with one or more halogen atoms or a pyrrolidinyl group, a C3-C6, a group of general formula: ** (See formula) * * in which R24 represents a C1-C4 linear or branched alkylene group, and R25 represents a group C1-C4, linear or branched, or R2 and R3, when taken together, represent a C3-C10 alkylene group, linear or branched, or represent with the nitrogen atom to which they are attached a group of general formula: ** (See formula) ** in which: - R26, R27, and R28, identical or different, represent hydrogen or a alkyl C1-C4, linear or branched, or - R26 represents hydrogen or an alkyl group C1-C4, linear or branched, and R27 and R28 when taken together represent a C1-C4 linear or branched, W, W alkylene group 'and Z are such that: - when W and W', which are identical represent CH, Z represents -O - or -S- - when W represents CH and W 'represents C-R13, Z represents -CH = C (R14) -, R13 and R14 being identical or different and representing hydrogen, a halogen atom, an alkyl radical C1 C4, or C1-C4 alkoxy radical, X represents -O- or -S-, wherein these derivatives benzofuran or benzothiophene as individual optical isomers or mixtures thereof.
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