Further evidence for coupling of sodium and proton movements in dog red blood cells.

Abstract Using 4,4′-diisothiocyanostilbene-2,2′-disulfonate (DIDS) and tributyltin the sodium transport pathway activated by shrinkage in dog red blood cells is shown to behave as expected for an electroneutral Na + /H + exchanger. When the driving forces for sodium and protons are equal, flow through the pathway stops. Amiloride inhibits the shrinkage-induced Na + /H + exchange.