Mid-term results of INTRABEAM intraoperative radiotherapy in St. Petersburg, Russia.

e12535Background: Postoperative radiotherapy reduces the risk of local recurrence after breast-conserving surgery in approximately 2/3 of cases. Target intraoperative radiotherapy of the tumor bed reduces the risk of local recurrence whereas addition of sentinel node biopsy (SNB) improves the long-term results in patients with breast cancer on early stages. Methods: A group of 129 patients with T1-2N0-1M0 breast cancer underwent breast-conserving surgery with SNB and intraoperative radiotherapy using the Intrabeam system immediately after surgical excision. The axillary lymphadenectomy was performed in all SNB-positive women. Patients with high-risk factors (young age, SNB-positive, Grade 3, lymphovascular invasion) received the planned external beam radiotherapy (typically 45–50 Gy in 25 fractions over 5 weeks) to the whole breast. Adjuvant chemotherapy or endocrinotherapy was performed after radiotherapy. The follow-up period involved 36 months. Results: There was ipsilateral recurrence in 2 patient (1....