Clinical observation of sunitinib treatment for refractory advanced breast cancer ulcer

Objective To observe the preliminary efficacies and adverse events of sunitinib in the treatment of metastatic breast cancer ulcer. Methods From December 2008 to May 2010,patients with advanced breast cancer ulcer took a single sunitinib.The dosage was adjusted on the basis of adverse events.And clinical response was evaluated. Results Nine patients with advanced breast cancer ulcer finished the treatment.The objective response and the clinical benefit time to progression of sunitinib were 3 and 7 patients with metastatic breast cancer ulcer,and the median time to progression (TTP) was 2.0 months.The most common adverse events included fatigue,hand-foot syndrome,neutropenia,thrombocytopenia and hypertension. Conclusion Single-agent sunitinib treatment of refractory advanced breast cancer ulcer has marked efficacies.However,neutropenia,thrombocytopenia and hypertension are the major dose-limited toxicities. Key words: Sunitinib; Advanced breast cancer; Ulcer