2 IntegratedCancerGenomicsDivision,TranslationalGenomicsResearchInstitute(TGen),Phoenix,Arizona 3 DepartmentofPreventiveMedicine,KeckSchoolofMedicine,UniversityofSouthernCalifornia,

BACKGROUND. African American men (AA) exhibit a disproportionate share of prostatecancer (PRCA) incidence, morbidity, and mortality. Several genetic association studies haveimplicated select 8q24 loci in PRCA risk in AA. The objective of this investigation is to evaluatethe association between previously reported 8q24 risk alleles and PRCA in African-Barbadian(AB) men known to have high rates of PRCA.METHODS. Ten previously reported candidate tag SNPs were genotyped and/or imputed inthe 8q24 region in 532 AB men with PRCA and 513 AB controls from the Prostate Cancer in aBlack Population (PCBP) study.RESULTS. Rs2124036 was significant in AB men, (OR¼2.7, 95% CI (1.3–5.3), P¼0.005,Empirical (max (T), corrected for multiple testing) P¼0.03) for the homozygous C/Cgenotype. Only a single SNP from this region remained statistically significant in our analysisof our AB population. These results may indicate the presence of a founder effect or due to thechosen SNPs not tagging an ancestral haplotype bearing the 8q24 risk allele(s) in this