Clinical comparison of radiolocalization of two monoclonal antibodies (mAbs) against the TAG-72 antigen

Abstract Ten patients with colorectal cancer metastases received 125 I-B72.3 and 131 I-CC49 prior to laparotomy (five patients received 1 mg, and five 20 mg of each mAb). Tumor:serum ratios of 131 I-CC49 were better than those of 125 I-B72.3 ( P P = 0.05 at 20 mg; P 125 I-B72.3 or 131 I-CC49. We conclude that mAb CC49 has better relative uptake in colorectal cancers than mAb B72.3.