Advanced One- and Two-Dimensional Mesh Designs for Injectable Electronics

The unique structure and mechanical properties of syringe-injectable mesh electronics have enabled seamless tissue integration and stable chronic recording of the activities of the same neurons on a year-scale. Here, we report studies of a series of structural and mechanical mesh electronics design variations that allow injection using needles at least four-fold smaller than previously reported to minimize the footprint during injection of the electronics in soft matter and tissue. Characterization of new ultra-flexible two-dimensional (2D) and one-dimensional (1D) probes has demonstrated reproducible injection of the newly developed mesh electronics designs via needles as small as 100 μm in inner diameter (ID) with reduced injection volumes. In vitro hydrogel and in vivo mouse brain studies have shown that ultra-flexible 2D and 1D probes maintain their structural integrity and conformation post-injection after transfer through the reduced diameter needles. In addition, analysis of the variation of the po...