A single bout of exercise influences natural killer cells in elderly women, especially those who are habitually active.
2005
The purpose of our study was to
examine the effects of a single exercise bout on the natural killer
(NK) cell count and activity in physically active elderly people,
sedentary elderly people, and sedentary young people. Eight elderly
women who trained by walking (age, 64 ± 1 years; V O2peak,
32.2 ± 1.1 ml·kg-1·min-1), 8 age-matched untrained women (63
± 1 years, 28.8 ± 1.0 ml·kg-1·min-1), and 8 young untrained
women (25 ± 1 years, 37.6 ± 1.6 ml·kg-1·min-1) were studied.
Blood samples were taken before, immediately after, and 2
hours after a 30-minute bout of exercise at an intensity equivalent
to 70�75% of V O2 peak. Peripheral blood mononuclear cells
were isolated and the NK cell count and activity were analyzed.
The NK cell count of the elderly sedentary group immediately
after exercise was significantly higher than those of the elderly
women who walked and young sedentary women, whereas no
significant interaction was detected in NK cell activity and NK
cell activity per cell number among the 3 groups. Consequently,
an intrinsic defect in the cytotoxic ability of NK cells appeared
in sedentary elderly people but not in active elderly people who
perform habitual exercise.
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