Abstract WMP99: Progression of White Matter Injury After Intracerebral Hemorrhage: An MRI Study

Background: White matter injury (WMI) is observed after experimental intracerebral hemorrhage (ICH). Supporting clinical data are sparse. We assessed the presence, extent, and progression of WMI in ICH patients. Methods: Retrospective review of data from consecutive 65 patients with spontaneous supratentorial ICH who had baseline brain MRI within 7 days of ICH onset and repeat MRI afterwards (median 83 days). We used Fazekas scale (FZS) to grade the severity of WMI. Clinical and imaging characteristics of patients with and without WMI progression were compared by uni- and multi-variate logistic regression analyses. Results: For the entire cohort, the mean total FZS score increased from 2.9±1.6 on baseline to 3.3±1.6 on repeat MRI (p=0.00; Z=-4.38). The progression of WMI was noted both ipsi- and contra-lateral to the ICH; the mean score increased from 2.9±1.6 to 3.1±1.5 (p=.00; Z=-3.56) in the contralateral hemisphere and 2.8±1.6.to 3.1±1.6 (p=.00; Z=-4.49) in the ipsilateral hemisphere. Similar results w...