Low Efficacy of Gene Therapy for Rat BT4C Malignant Glioma Using Intra-Tumoural Transduction with Thymidine Kinase Retrovirus Packaging Cell Injections and Ganciclovir Treatment

Anu-Maaria Sandmair,Sami Loimas,Harish Poptani,Pauli Vainio,Ritva Vanninen,Marita Turunen,Kristiina Tyynelä,Matti Vapalahti,Seppo Ylä-Herttuala

Low Efficacy of Gene Therapy for Rat BT4C Malignant Glioma Using Intra-Tumoural Transduction with Thymidine Kinase Retrovirus Packaging Cell Injections and Ganciclovir Treatment

1999

Anu-Maaria Sandmair
Sami Loimas
Harish Poptani
Pauli Vainio
Ritva Vanninen
Marita Turunen
Kristiina Tyynelä
Matti Vapalahti
Seppo Ylä-Herttuala

Background. The purpose of this study was to test the use of Herpes Simplex virus thymidine kinase (HSVtk) retrovirus packaging cell injections in the treatment of malignant brain tumours.

Keywords:

Surgery
Virus
Glioma
Cell
Herpes simplex virus
Genetic enhancement
Retrovirus
Ganciclovir
Thymidine kinase
Medicine
genetic transfer

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