Organ-specific microcirculatory mass transport of oxycodone in humans: clinical implications for therapeutic use.

Objectives:To begin to address the problem of heterogeneity of distribution of oxycodone (OC) in humans, we developed an organ-specific microcirculatory capillary-tissue exchange 2-compartment model for studying regional OC mass transport.Materials and Methods:The model was developed in silico. It q