Multiple Myeloma and Monoclonal Gammopathy of Unknown Significance

HIV-infected individuals have a higher risk to develop both a monoclonal gammopathy (MG) and a multiple myeloma (MM) as compared to the general population. If a MG appears with a low M spike without other symptoms and signs, it is called MG of undetermined significance (MGUS). The prevalence of MG among HIV infected patients in the HAART era is 3–5 %.