Anti-radiation effect of TiO2 nanoparticles given to Kunming mouse

Objective To evaluate the anti-radiation effect of TiO2 nanoparticles at different concentration levels on mice.Methods Kunming mice aged 6-8 weeks were selected to receive whole body radiation of 6.5 Gy γ-ray.The mice of experimental groups were treated with 10,20 and 40 mg/kg TiO2 nanoparticles respectively.Before radiation,the above mice received two consecutive days of treatment of intraperitoneal injection.Continuously,mice were administered by TiO2 nanoparticles for another post-radiation day.The white blood cell count (WBC),platelet count (PLT),hemoglobin count (HGB),bone marrow nuclear cell (BMNC),bone marrow DNA and superoxide dismutase (SOD),malonaldehyde (MDA) of liver and lung were counted and the organs indices were calculated by weighing liver,spleen and thymus to assess the radiation-protection effect of TiO2 nanoparticles.Results Compared with those in the control group,the parameters of treatment groups (excluding MDA) increased and statistical difference between the high-dose groups and control mice were detected (P＜0.05).Conclusions TiO2 nanoparticles injection showed a short-term radiation-protection effect on Kunming mice and the effect of high-dose is better than low-and middle-dose. Key words: TiO2 nanoparticles;  Radiation;  Protection