Micro X-Ray Fluorescence As A High Throughput Screening Method For Combinatorial Chemistry

Micro X-ray fluorescence is used as a high-throughput screening method for combinatorial applications. These include chemical weapon degradation products, catalytic phosphate hydrolysis and radiologic dispersion device metals. In each application the intrinsic elemental signature was utilized to identify the lead hits for the combinatorial screening in locating peptide sequences exhibiting the desired binding characteristics. In addition to being nondestructive, rapid and non-perturbing to the binding event, this method can be used to quantify the amount of target material.