An intra-operative feature-based classification of microelectrode recordings to support the subthalamic nucleus functional identification during deep brain stimulation surgery.

OBJECTIVE The Subthalamic Nucleus (STN) is the most selected target for the placement of the Deep Brain Stimulation (DBS) electrode to treat Parkinson's disease. Its identification is a delicate and challenging task which is based on the interpretation of the STN functional activity acquired through microelectrode recordings (MER). Aim of this work is to explore the potentiality of a set of twenty-five features to build a classification model for the discrimination of MER signals belonging to the STN. APPROACH We explored the use of different sets of spike-dependent and spike-independent features in combination with an Ensemble Trees classification (ET) algorithm on a dataset composed of thirteen patients receiving bilateral DBS. We compared results from six subsets of features and two dataset conditions (with and without standardization) using performance metrics on a leave-one-patient-out validation schema. MAIN RESULTS We obtained statistically better results (i.e., higher accuracy p-value = 0.003) on the raw dataset than on the standardized one, where the selection of seven features using a minimum redundancy maximum relevance (MRMR) algorithm provided a mean accuracy of 94.1%, comparable with the use of the full set of features. In the same conditions, the spike-dependent features provided the lowest accuracy (86.8%), while a power density-based index was shown to be a good indicator of STN activity (92.3%). SIGNIFICANCE Results suggest that a small and simple set of features can be used for an efficient classification of microelectrode recordings to implement an intraoperative support for clinical decision during deep brain stimulation surgery.