2,3-dimethyl-6-indazole -2h- urea compounds, preparation method and application

The present invention discloses a 2,3-dimethyl represented by the following general formula (Ⅰ) -6- urea -2H- indazole compound, or a pharmaceutically acceptable salt solvate, Ar is a substituted or unsubstituted benzene an aryl group or a heteroaryl group. The present invention also discloses a preparation method and use of the above compounds. Compounds of the invention capable of modulating tyrosine kinase signal transduction, inhibiting undesirable cell proliferation, in particular tumor having a significant effect.