Biochemical Effects on the Liver and Kidney of Rats Administered Aqueous Leaf Extract of Guira Senegalensis

Effect of crude aqueous extract of guira senegalens is on liver and kidney of albino rats have been investigated. The l evels of serum alanine aminotransferase (ALT) and aspartate aminotransfera se (AST) of treated animals have significantly increased compared to th e control group. Increased levels of these enzymes appeared dose dependent. Bo th ALT and AST have significantly (p>0.005) increased in animals treate d with the highest dose (900mg/kg) compared to the control and other treate d groups. Similarly, serum levels of urea and creatinine of treated animals ha ve significant (p<0.005) increase compared to the control group. The result is suggestive of liver and kidney impairment by the crude extract.