Recent advances towards the synthesis of 4H-quinolizin-4-one

Abstract 4H-quinolizin-4-one's is an important heterocyclic compound due to its wide range of applications in medicinal chemistry and material science. Despite of the attractive physicochemical properties and interesting biological activities, due to the non-availability of a general method of the synthesis, 4H-quinolizin-4-one's small molecule library under-represented in medicinal chemistry programs. Therefore, the development of the general methods for the constructions of this core is an area of interest. Which continue to attract from the synthetic organic community and many protocols for the synthesis of functionalized 4H-quinolizin-4-one were appeared in the literature since 2000. In this review, the results of the synthetic efforts towards the synthesis of the quinolizinone since 2000 are reviewed.