Two Heteroligand Cd(II)-coordination Polymers: Crystal Structures and Anti-Lung Cancer Activity Evaluation

Two new Cd(II) containing coordination polymers, namely {[Cd(Dib)(1,4-Ndc)] · H2O}n (I, Dib = 1,4-di(1H-imidazol-1-yl)butane, 1,4-H2Ndc =  naphthalene-1,4-dicarboxylic acid) and [Cd(2,2′-Dsb)-(Dpe)-(DMF)(H2O)] (II, 2,2′-H2Dsb = 2,2′-disulfanediyldibenzoic acid, Dpe = (E)-1,2-di(pyridin-4-yl)ethene), have been successfully prepared under the hydrothermal or solvothermal conditions by using the carboxylic acid and N-donor linkers with different functional groups as the co-ligands. Furthermore, the CCK-8 assay was performed to detect the inhibitory effect of these two synthetic complexes on the NCI-H292 lung cancer cell line. The mechanism of the complexes anti-cancer activity was explored with Annexin V-FITC/PI apoptosis detection and western blot assay.