Multifunctional nuclear shell structure drug carrier material and preparation method thereof

The invention provides a multifunctional nuclear shell structure drug carrier material and a preparation method thereof; the preparation method comprises the following steps: step one, adopting a solvent-thermal method for preparing monodispersed ferroferric oxide magnetic nanoparticles with grain diameter of about 60nm as ferromagnetic nuclear material of the nuclear shell structure; step two, adopting a sol-gel method for cladding an imporous silicon dioxide layer and a meso-porous layer outside ferromagnetic nucleus in sequence; step three, adopting the sol-gel method for loading a layer ofup-conversion fluorescent material NaYF4: Yb, Er on the material obtained in the step two, wherein the molar concentration of Yb occupies 17% of Y concentration, and the molar concentration of Er occupies 3% of Y concentration. In the invention, an inertia SiO2 layer is designed between the magnetic nucleus and post-functionalized rare earth luminescent material for separating magnetic material from a rare earth luminescent layer so as to prevent fluorescent quenching; up-conversion fluorescent powder with higher fluorescent efficiency is used as fluorescent material; and the sol-gel method with mild reaction condition and uniform dispersion is adopted for forming the nuclear shell structure.