Therapeutic effect with domiciliary non-invasive positive pressure ventilation for a year in patients with chronic obstructive pulmonary disease

Objective To detect the effection of non-invasive positive pressure ventilation in the severe chronic obstructive pulmonary disease (COPD) patients with hypercapnemia. Methods The severe COPD patients compared with hypercapnemia were divided into two groups: the mechanical ventilation group( n = 20), patients accept long-term domiciliary non-invasive positive pressure ventilation. The control group( n = 26). Followed up a year. The FEV1, FVC, SGRQ scores, PSQI, arterial gasometry,MMRC dyspnea scale were carried out in the day of hospital discharge and a year after hospital diacharge.mechanical ventilation group was no statistically significant different compared to the control group in the severe COPD patients with hypercapnemia( P >0.05), however, the PCO2 were statistically significant different( P a year ( P< 0.05 ), while it increased significantly after a year in the control group ( P < 0.05 ).Conclusions Long-term domiciliary non-invasive positive pressure ventilation have no benefit for the lung faction for the stable COPD patients with chronic hypercapnie, But can reduce the artery PCO2. Releaving hypoxia. Improving life statues. Reducing the frequency of hospitalization. Improving the exercise tolerance. No obviously effect for PSQI scores. Key words: Chronic obstructive pulmonary disease;  Long-term domiciliary non invasive positive pressure ventilation;  Lung function;  Arterial gasomctry;  SGRQ scores