FRI0498 HIGH SERUM URIC ACID LEVEL IS ASSOCIATED WITH LOWER INCIDENCE OF OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN: DATA FROM THE KOREAN NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY

Background Osteoporosis is one of the most common morbidities in postmenopausal women. Although serum uric acid (SUA) accounts for about 50% of extracellular antioxidant activity, the role of hyperuricemia in osteoporosis, a condition characterized by high oxidative stress level, has not been investigated in a Nation-wide scale. Objectives The aim of this study is to evaluate an association between SUA and incidence of osteoporosis in postmenopausal women. Methods Data of postmenopausal women from the 2016 Korean National Health and Nutrition Examination Survey were included and retrospectively analyzed. Weighted prevalence and logistic regression analysis were used to determine the incidence of osteoporosis and the effect of SUA on osteoporosis in postmenopausal women. Results One-thousand three-hundred eighty-two (weighted n = 7,064,137) of postmenopausal women were observed. Of these, 401 (29.0%, weighted n = 1,880,586) women developed osteoporosis. Mean age of participants was 63.2 years and mean of SUA was 4.4 mg/dL. The effect of SUA on osteoporosis in postmepausal women was not statistically significant according to univariable logistic regression (OR 0.977, 95% CI 0.855-1.116, p = 0.729). However, SUA was negatively associated with incidence of osteoporosis in postmenopausal women with statistical significance after adjusting for age, obesity, amount of drink, smoking, intake of calcium, rheumatoid arthritis, thyroid diseases, and loss of activity (OR 0.867, 95% CI 0.752-0.999, p = 0.048). Conclusion Our data demonstrated that high SUA is associated with lower incidence of osteoporosis in postmenopausal women. This result suggests a protective role of SUA in metabolic bone diseases. References [1] Hernlund E, Svedbom A, Ivergard M, Compston J, Cooper C, Stenmark J, et al. Osteoporosis in the European Union: medical management, epidemiology and economic burden. A report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA). Arch Osteoporos. 2013;8:136. [2] Varacallo MA, Fox EJ. Osteoporosis and its complications. Med Clin North Am. 2014;98(4):817-31. [3] Wauquier F, Leotoing L, Coxam V, Guicheux J, Wittrant Y. Oxidative stress in bone remodelling and disease. Trends Mol Med. 2009;15(10):468-77. [4] Lee NK, Choi YG, Baik JY, Han SY, Jeong DW, Bae YS, et al. A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation. Blood. 2005;106(3):852-9. [5] Bai XC, Lu D, Liu AL, Zhang ZM, Li XM, Zou ZP, et al. Reactive oxygen species stimulates receptor activator of NF-kappaB ligand expression in osteoblast. J Biol Chem. 2005;280(17):17497-506. Disclosure of Interests None declared