Digestive tract absorption of alkyl α-cyanoacrylate-β-14C

Abstract Absorption and assimilation of methyl and n -butyl α-cyanoacrylate-β- 14 C was evaluated in the digestive tract of the rat. By evaluating the urine for carbon-14, it was demonstrated that there is absorption of monomer and/or polymer degradation products of cyanoacrylate when applied as a monomer and allowed to polymerize on the oral mucosa. It was also demonstrated that if these materials in polymer form were to be inadvertently swallowed, degradation and assimilation of a significant percentage of the polymer would occur.