Live-attenuated respiratory syncytial virus vaccine candidate with deletion of RNA synthesis regulatory protein M2-2 is highly immunogenic in children

Elizabeth J. McFarland,Ruth A. Karron,Petronella Muresan,Coleen K. Cunningham,Megan Valentine,Charlotte Perlowski,Bhagvanji Thumar,Devasena Gnanashanmugam,George K. Siberry,Elizabeth Schappell,Emily Barr,Vivian Rexroad,Ram Yogev,Stephen A. Spector,Mariam Aziz,Nehali Patel,Mikhaela Cielo,Cindy Luongo,Peter L. Collins,Ursula J. Buchholz

Live-attenuated respiratory syncytial virus vaccine candidate with deletion of RNA synthesis regulatory protein M2-2 is highly immunogenic in children

2018

Background Live respiratory syncytial virus (RSV) candidate vaccine LIDΔM2-2 is attenuated by deletion of the RSV RNA regulatory protein M2-2, resulting in upregulated viral gene transcription and antigen expression but reduced RNA replication.

Keywords:

Antibody
Virology
Regulation of gene expression
Virus
Immunogenicity
Transcription (biology)
Pathogenicity
Respiratory system
RNA chemical synthesis
Medicine
Plaque-forming unit
Rhinovirus
Antibody titer
Reactogenicity
Immunology
Infectivity
Enterovirus

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