Effect of acid blockade on gastric histamine in mice.

Vagotomy and omeprazole effectively inhibited 2-deoxy-d-glucose (−91%) and pentagastrin (−72%) stimulated acid production in mice, respectively. Both vagotomy and omeprazole treatment were accompanied by massive increases in histamine secretion (8-fold or more, during both basal and stimulated states). Mucosal stores of histamine, however, were not depleted. Similar rises in luminal histamine have been observed in patients treated in these ways. The mouse model may thus be suitable to elucidate the kinetics of histamine release in patients.