Autologous skeletal myoblast transplantation improves hemodynamics dogs with chronic heart failure dogs

Objective To test the effects of autologous skeletal myoblast transplantation on the hemodynamics in dogs with coronary microembolization-induced chronic heart failure (CHF). Methods CHF models were successfully induced in 19 dogs and divided into ASMT group (n=9) and control group (n=10). The myoblasts were injected into the embolized region in the 9 dogs of the ASMT group, and saline was injected in the control dogs, and the hemodynamics of the dogs were evaluated 5 weeks after the injections. Result Compared with saline injection, ASMT significantly increased dP/dtmax, MAP and LVSP (P0.05) and decreased LVEDP (P0.05) 5 weeks after myoblast transplantation. Desmin and Brd-U immunofluorescent staining showed myoblast survival at the injected sites in the dogs. Conclusion ASMT provides mild improvements in the hemodynamics of dogs with CHF.