Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene
2010
Alfons Meindl and colleagues report heterozygous germline mutations in RAD51C in families with breast and ovarian cancer. Mutations were found in 1.3% of 480 pedigrees with breast and ovarian cancer, but not in 620 pedigrees with breast cancer only.
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