Highly Pathogenic Porcine Reproductive and Respiratory Syndrome

Porcine reproductive and respiratory syndrome (PRRS) is an important viral disease in pigs, causing economic losses worldwide. In 2006, highly pathogenic pig disease, which was characterized by high fever, depression, anorexia, red discoloration of the body, and blue ears associated with high mortality, emerged in China. The atypical PRRS virus was isolated from affected pigs, which was identified a deletion of 30 amino acids in its NSP2. After outbreak in China, this highly pathogenic PRRS spread to Southeast Asia. This paper review the history of highly pathogenic PRRS, the situation of the outbreak of highly pathogenic PRRS in China and Vietnam, the molecular characterization of highly pathogenic PRRS virus, and clinical signs and gross lesions of highly pathogenic PRRS.