Periodic limb movements of sleep in patients with history of stroke

falling asleep after both M1 and S1 stimulation; the overall quality of sleep did not change significantly. The single-pulse TMS assessment, repeated after each session, showed a more prolonged CSP after M1 stimulation compared with baseline and a trend toward an higher rMT value, whereas MEPs amplitude remained basically unchanged; conversely, S1 and sham stimulations did not produce any variation. No clinical or neurophysiological effect was observed in healthy controls. Conclusion: The distinctive profile to TMS related to motor and somatosensory complaints we found in RLS patients might be considered a target of specific repetitive paradigms of stimulation. If this study provides valuable information at the individual level, TMS might prompt a design of an instrument for an innovative nonpharmacological approach. Acknowledgements: This study was supported by a grant of the Italian Ministry of Health (“Ricerca Corrente”).