Perinatal outcomes among singletons after assisted reproductive technology with single-embryo or double-embryo transfer versus no assisted reproductive technology

Objective To examine outcomes of singleton pregnancies conceived without assisted reproductive technology (non-ART) compared with singletons conceived with ART by elective single-embryo transfer (eSET), nonelective single-embryo transfer (non-eSET), and double-embryo transfer with the establishment of 1 (DET −1) or ≥2 (DET ≥2) early fetal heartbeats. Design Retrospective cohort using linked ART surveillance data and vital records from Florida, Massachusetts, Michigan, and Connecticut. Setting Not applicable. Patient(s) Singleton live-born infants. Intervention(s) None. Main Outcome Measure(s) Preterm birth (PTB Result(s) After controlling for maternal characteristics and employing a weighted propensity score approach, we found that singletons conceived after eSET were less likely to have a 5-minute Apgar Conclusion(s) Compared with non-ART singletons, singletons born after eSET and non-eSET did not have increased risks whereas DET −1 and DET ≥2 singletons were more likely to have adverse perinatal outcomes.