Effect of naloxone combined with HFOV in resuscitation of premature infants with asphyxia

Objective To observe the effect of naloxone combined with high frequency oscillatory ventilation (HFOV) in the resuscitation of premature infants with asphyxia. Methods From Jul. 2012 to Dec. 2016, a total of 400 premature infants with asphyxia treated at our hospital were taken as the clinical objects and were divided into a study group (210 cases) and a control group (190 cases). Both groups were given naloxone; besides, the study group was given HFOV. The clinical data of these patients were retrospectively analyzed. And the effects of two different resuscitation measures for premature infants with asphyxia were compared and analyzed. Results The markedly effective and effective cases in the study group were significantly more than those in the control group; and the invalid cases in the study group were fewer than those in the control group; the total effective rate in the study group was 86.66%, which was significantly higher than that in the control group (60.00%). The breathing, crying, muscle tension, primitive reflex, and birth weight recovery times in the study group were all shorter than those in the control group, with statistical differences (allP<0.05). Conclusion HFOV combined with naloxone whose recovery effect is better than single use of naloxone and can not only effectively relieve respiratory depression for premature infants with asphyxia, but also promote the recovery of spontaneous breathing mechanism. Key words: Naloxone; HFOV; Premature infants with asphyxia; Resuscitation