Assessment of betamethasone-in-cyclodextrin-in-liposome induced skin blanching response

The aim of this study is to evaluate the skin blanching induced effect of liposomes containing a betamethasone-cyclodextrin (HPγCD) complex solution and to compare the obtained effect to that of different preparations containing 0.1 % betamethasone. Inclusion of betamethasone in HPγCD allows to obtain high betamethasone encapsulation levels in liposomes. Liposomes are supposed to increase the efficacy of betamethasone and to obtain an extended release of betamethasone.