Prognosis with Proton Pump Inhibitor Versus H2 Blocker Therapy in Clostridium Difficile Infection

An 83-year-old female patient recovered from her primary Clostridium difficile-associated colitis upon antibiotic treatment and the suspension of her regular proton pump inhibitor (PPI) therapy, and had a recurrence of the infection once PPI was restarted. After the treatment of the recurrent episode, the PPI was replaced with a histamine H2 receptor blocker, and she developed no more relapses. The switch from PPI to a H2 blocker may have been a recovery factor. More research is encouraged to clarify the extent of the suggested effect.