Spinal metastasis of cerebral Glioblastoma (GBM) with genetic profile: case report and review of literature.

Abstract Spinal metastasis of cerebral glioblastoma (GBM) is very rare, with some reports suggesting a prevalence of 1-2%. (1) Herein, we present 2 unique cases of spinal metastasis of cerebral GBM, one of which was histologically proven to be a drop spinal GBM metastasis. The first case was a 25-year-old female who presented with a spinal intradural intramedullary spinal lesion a few months after resection of a left temporal lobe GBM (IDH wild type). The patient underwent surgical resection of the new lesion, and subsequent histopathological examination proved that the intramedullary spinal lesion was GBM. The patient experienced full recovery post operatively, and then a few months later, she presented again with widespread drop metastasis of the spinal cord. The second case is a middle-aged male with right temporal GBM who developed spinal metastasis 10 months after his diagnosis. We are reporting these two cases due to the rarity of spinal metastasis in GBM. We reviewed the current literature and included genetic and molecular profiles in the discussion. Currently, there are no established treatment guidelines for GBM spinal metastasis. The Stupp protocol after initial brain surgery for GBM did not appear to have beneficial effects on prolonging survival in these patients with spinal metastasis. The goal of treatment was primarily to alleviate pain and neurological deficits with no effect on overall outcome. Prognosis following the diagnosis of spinal metastasis is poor.