Identification of antibodies against Diego B in the context of a hemolytic disease of the newborn

Since its discovery in 1953, the presence of the antigen Diego (Di) has been related to the Mongoloid populations and American natives. Given its immunogenic potential, the presence of the mentioned antigen is related to the development of hemolytic disease of the newborn (HDN). We present the case of a puerperal patient with no known history who was detected the presence of antibodies to Di b during study of a mild HDN presented by her daughter. When studying the patient's family, the presence of Dib antigen was reported in a brother as well as in both parents. We consider that being a rare event, this type of case should be reported promptly to promote the exchange of knowledge with other health professionals and the community.