Genes envolvidos no controle do desenvolvimento inicial do rim

As doencas renais humanas sao uns dos maiores problemas de saude, e varios genes quecontrolam a nefrogenese estao associados com essas doencas. Os principais genes envolvidosno desenvolvimento inicial do rim sao PAX2, EYA1, SIX1 E 2, SALL1, FOXC1, WT1, HOX11, e amaioria dos fatores transcricionais desses genes e importante na regulacao do gene GDNF. Essesgenes interagem uns com os outros, formando uma especie de rede genetica. O estudo dessasinteracoes geneticas e essencial para o entendimento das bases moleculares das malformacoesdo desenvolvimento renal, que e necessario para a prevencao e tratamento dessas desordens. Renal human diseases are among the leading health problems and many genes that controlnephrogenesis are associated with these diseases. The main genes involved in early kidneydevelopment are PAX2, EYA1, SIX1 and 2, SALL1, FOXC1, WT1, HOX11, and the majority oftheir transcriptional factors are relevant to the regulation of GDNF. Those genes interact with oneanother to create a genetic network. The study of such genetic interactions is crucial forunderstanding the molecular basis of kidney development malformations, which is necessary forthe prevention and treatment of these disorders.