Self-Ranging Thumb-sized Multichannel Electrochemical Instrument for Global Wearable Point-of-Care Sensing

This paper presents a self-ranging, multichannel, multi-technique electrochemical instrument with the size, power, and performance suitable for wearable applications, such as point-of-care sensing. It comprises a custom analog interface and a commercial low-power microcontroller and hosts two independent readout channels that are capable of dynamically adjusting to a wide range of input currents exhibited by various electrochemical sensors. To evaluate its functionality and versatility, the system was tested with multiple sensors using multiple electrochemical methods and was benchmarked against two commercial electrochemical instruments. While occupying only 8.5 cm 3 and consuming an average active power of 250 mW, the instrument provides nearly 10-bit accuracy over a 115 dB dynamic operational range and matches benchtop instrument results within 1.8%, demonstrating its capability to serve as a universal wearable electrochemical instrument.