Tritoqualine and some aspects of histamine metabolism

The influence of in vivo tritoqualine (Inhibostamin) given to mice as a single dose (100 mg/kg) or subchronically (40 mg/kg daily for 5 days) has been examined on 1. histamine release from peritoneal mast cells, 2. histamine level in some tissues, and 3. intestinal diamine oxidase activity. The effects of tritoqualine and alpha-hydrazinohistidine injected into eggs on the 16th, 17th or 18th day of chick embryo age on hatching time, histamine level and diamine oxidase (DAO) activity in brood's tissues were also examined. After a single administration of tritoqualine there was a drop of histamine level in brain, a similar tendency being observed in kidney and lung, and an opposite effect in intestine. With the latter coincides the reduced intestinal DAO. Subchronical treatment changes pattern of anti-IgE induced histamine release from mast cells, slightly reduces histamine content in brain, kidney and lung, and transiently increases intestinal DAO. Neither tritoqualine nor alpha-hydrazinohistidine influenced time of hatching. Both drugs differ in respect to direction and intensity of changes they evoke in histamine content and DAO activity in examined organs.