Repair for infectious open fracture after seawater immersion with artificial material

Objective To explore the alterations on pathology and fracture callus growth imaging when using artificial material to repair for the open fracture with infection after seawater immersion.Methods Osteotomy was conducted in the middle part of ulna on an adult dogs,and 2 centimeters animal model of open fractures and bone defect were made.The test group was immersed in seawater and the control group was exposed in the air for two hours.Secretion from infected wound was taken for germiculture and drug susceptibility testing.48 dogs were bacterial infection,including 24 dogs in control group.The test group was divided into two subgroups randomly.Wound debridement was carried out.12 dogs were given nanomaterials bone and 12 dogs were implanted with calcium phosphate cement(CPC) solidified body respectively.The control group was carried out same as test group.All the experimental animals are fixed by using the glass fiber plaster bandage,and then were given sensitive antibiotics muscle injections regularly.The histopathological and imaging changes of animal bone defect fracture were observed for 12 weeks.Results There was a significant difference in pathological examination between the test and control group(P0.05).A significant difference of repair degree was observed between the nanomaterials bone and CPC solidified body implants(P0.01).Conclusion The effect of artificial material repair for the open fracture with infection after seawater immersion is inferior to that of exposed to air.Hoever,the effect of CPC solidified body implants is superior to that of the nanomaterials bone.