(+)-/(-)-Prunomarin A and (+)-pestalactone B, three new isocoumarin derivatives from the endophytic fungus Phomopsis prunorum
2021
Abstract Three pairs of isocoumarin enantiomers, (±)-prunomarin A (1), (±)-pestalactone B (2), and (±)-3, including three new compounds, (+)-/(−)-1 and (+)-2, were isolated from the endophytic fungus Phomopsis prunorum (F4-3). These enantiomeric pairs were existed as partial racemates and were achieved by chiral-HPLC separation. Their structures were elucidated by comprehensive spectroscopic data, X-ray diffraction, and ECD analysis. Compounds (±)-1 represented the first examples of naturally occurring sulfoxide-containing isocoumarin derivatives. Compound 1 showed anti-inflammatory activity for NO production with an IC50 value of 84.2 µM. Compounds (+)-/(−)-3 exhibited strong phytotoxicity against Amaranthus retroflexus.
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
20
References
0
Citations
NaN
KQI