Altered Lipid Domains Facilitate Enhanced Pulmonary Vasoconstriction Following Chronic Hypoxia

Charles E. Norton,Laura Weise Cross,Rosstin Ahmadian,Simin Yan,Nikki L. Jernigan,Michael L. Paffett,Jay S. Naik,Benjimen R. Walker,Thomas C. Resta

Altered Lipid Domains Facilitate Enhanced Pulmonary Vasoconstriction Following Chronic Hypoxia

2020

Charles E. Norton
Laura Weise Cross
Rosstin Ahmadian
Simin Yan
Nikki L. Jernigan
Michael L. Paffett
Jay S. Naik
Benjimen R. Walker
Thomas C. Resta

Chronic hypoxia (CH) augments depolarization-induced pulmonary vasoconstriction through superoxide-dependent, Rho kinase-mediated Ca2+ sensitization. NADPH oxidase and epidermal growth factor recep...

Keywords:

Pharmacology
Hypoxic pulmonary vasoconstriction
Immunology
Hypoxia (medical)
Biology
Pulmonary hypertension
Nicotinamide adenine dinucleotide phosphate
membrane cholesterol
Caveolin 1
Caveolae
Sensitization
chronic hypoxia

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