Palladium-Catalyzed C(sp2)—H Cyanation Using Tertiary Amine Derived Isocyanide as a Cyano Source.

An unprecedented palladium-catalyzed cyanation of aromatic C–H bonds by using tertiary amine derived isocyanide as a novel cyano source was developed. Cu(TFA)2 was used as a requisite stoichiometric oxidant. Mechanistic studies suggest that a tertiary carbon cation-based intermediate is involved following the C–N bond breakage.