Influence of Metabolic Genotyping on Weight Loss and Body Composition in Women Participating in a 6 Month Diet and Exercise Program: Preliminary Findings

This study examined whether genetic profile influences response to a diet and exercise intervention. 53 sedentary women (38±12 yrs, 80.8±13.9 kg) were randomized to a control group (C) or exercise + diet groups. Those in exercise groups performed circuit resistance-exercise (4 d/wk) and walked (10,000 steps, 3 d/wk). Diets were 1,500 kcal/d with 20:35:45 (CI), 30:25:45 (CII) or 55:30:15 (AHA) percentages of CHO:FAT: PRO. Buccal cheek swabs were obtained at baseline and analyzed for FABP2, PPARG, ADRB-79, ADRB3, and ADRB-46 genes to determine true (T) or false (F) genetic matches to higher CHO or CHO restricted diets. Body weight and DEXA body composition measurements were obtained at 0, 4, 8, 12, 16, 20, and 24 wks. Data were analyzed by MANOVA and are presented as changes from baseline. An overall Wilk's Lambda time x diet (p=0.085) and time x diet x genotype (p=0.102) trend was observed. Univariate analysis revealed significant interaction trends in fat mass (C: 0.39±1.26; CI: T -6.16±5.04, F -1.58±2.22...