Non-extracorporeal circulation for coronary artery bypass graft surgery is more beneficial than extracorporeal circulation

OBJECTIVE : The objective of this study was to compare coronary artery bypass graft (CABG) surgery with non-extracorporeal vs. extracorporeal circulation. The study out - comes included operative time, number of graft vessels,pulmonaryinfectionrates,andsystemic inflammatorymarkers. PATIENTS AND METHODS: 96 patients re - ceived selective CABG, either with non-extracor - poreal (study group; n = 48) or extracorporeal circulation (control group; n = 48). Operative time, pulmonary infection rates, and blood levels of inflammatory markersTNF- α, IL-6, and IL-8 be - fore and 4, 24, and 48 hours after the surgery were quantified. Graft vessels were quantified using computed tomography. RESULTS: Operative time was significantly shorter in study group (4.58 ± 0.91 vs. 5.36 ± 1.12 hours in control group; p < 0.05). The number of graft vessels and pulmonary infection rates were comparable between both techniques. However, systemic inflammatory markers were significant - ly ( p < 0.05) lower in study group at 4 and, partly, 24 hours after the surgery. CONCLUSIONS: Extracorporeal circulation prolongs operation and can aggravate systemic inflammatory response. Therefore, CABG with non-extracorporeal circulation offers more bene - ficial outcomes.