A Convenient Synthesis of Enantiopure Paraconic Acid - A Key Intermediate in the Synthesis of A-Factor.

James M. Crawforth,Bernard J. Rawlings

A Convenient Synthesis of Enantiopure Paraconic Acid - A Key Intermediate in the Synthesis of A-Factor.

2010

James M. Crawforth
Bernard J. Rawlings

Abstract Enantiopure (S)-(−)-paraconic acid 2 has been synthesised by the stereospecific benzyloxymethylation of a titanium enolate derived from a homochiral oxazolidinone and dihydrocinnamoyl chloride.

Keywords:

Paraconic acid
Enantiopure drug
Chemistry
Organic chemistry

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